{"id":21952,"date":"2018-08-09T15:43:10","date_gmt":"2018-08-09T19:43:10","guid":{"rendered":"https:\/\/ncseagrant.ncsu.edu\/currents\/?p=10613"},"modified":"2024-05-21T15:54:08","modified_gmt":"2024-05-21T19:54:08","slug":"blue-bloods-spawn-new-research-partnership","status":"publish","type":"post","link":"https:\/\/ncseagrant.ncsu.edu\/coastwatch\/blue-bloods-spawn-new-research-partnership\/","title":{"rendered":"Blue Bloods Spawn New Research Partnership"},"content":{"rendered":"

Horseshoe crabs emerge in droves to spawn along the coast of Delaware Bay. Photo by Gregory Breese\/USFWS<\/em><\/p>\n

By ANTHONY DELLINGER<\/h3>\n

Anthony Dellinger is the president and chief scientist of Kepley BioSystems Inc., based in Greensboro, N.C. <\/em><\/p>\n

You\u2019ve perhaps heard about the vital role that Atlantic horseshoe crabs<\/a>\u00a0(Limulus polyphemus<\/em>) play in sustaining various migratory shorebirds. During stopovers in Delaware Bay, for instance, species such as red knots, ruddy turnstones and sanderlings gorge on horseshoe crab eggs for fuel.<\/p>\n

Beyond their ecological importance, however, horseshoe crabs are valuable sources of bait for the eel and whelk fishing industries. They\u2019re also critical to modern medicine.<\/p>\n

The bulk of horseshoe crab blood is comprised of unique cells called amebocytes. When amebocytes are exposed to microorganisms known as gram-negative bacteria<\/a> \u2014 such as E. coli<\/em> and Salmonella<\/em> \u2014 they form a clot around the pathogen, preventing infection from spreading.<\/p>\n

\"\"These specialized cells form the basis for the most widely used, FDA-approved safety assay for detecting contamination<\/a>\u00a0from gram-negative bacteria in injectable drugs and implantable medical devices. Called the Limulus<\/em> Amebocyte Lysate assay, or LAL for short, the method confirms whether or not those products are safe for patient use.<\/p>\n

Each year, about 500,000<\/a> horseshoe crabs are collected from the Atlantic seaboard for their distinctively blue blood. Most are taken while spawning. While the majority of crabs are returned to the water after their blood is harvested, an estimated 15 percent<\/a> don\u2019t survive.<\/p>\n

\u201cAlthough horseshoe crabs are returned to the wild after biomedical bleeding procedures, the associated stress on the animal leads to high mortality rates and can alter reproduction in female crabs,\u201d explains Jordan Krisfalusi-Gannon, an undergraduate at High Point University and a research technician at Kepley BioSystems, based in Greensboro.<\/p>\n

The crabs often suffer from oxygen deprivation during transportation to and from the bleeding facilities and receive little care or food to ensure their well-being.<\/p>\n

\u201cThese practices have become entirely unsustainable, as the impact on horseshoe crab reproduction and behavior has been compounded by such mortality rates and rapid industry growth,\u201d says Rachel Kulberg, senior research scientist at Kepley BioSystems. \u201cMany believe that continued medical industry growth will lead to the collapse of this species,\u201d she adds.<\/p>\n

In June, Kepley BioSystems researchers published a review in Frontiers in Marine Science<\/em><\/a> that describes innovative efforts to improve how horseshoe crab blood is harvested. The ultimate goal is to ensure a sustainable supply of blood while also conserving the species.<\/p>\n

In 2017, our company received a North Carolina Sea Grant minigrant<\/a> to support these efforts. \u201cWe are excited about this industry partnership,\u201d says John Fear, Sea Grant\u2019s deputy director. \u201cWe hope the results will help ensure the viability of the horseshoe crab population and the species\u2019 role in coastal ecosystems.\u201d<\/p>\n

A New Kind of Bait<\/h3>\n
\"\"
A blue crab rests next to some OrganoBait.<\/figcaption><\/figure>\n

The horseshoe crab project is the second partnership for Kepley BioSystems and North Carolina Sea Grant. Our company earlier received a minigrant to establish the feasibility of a synthetic crab and lobster bait that we named OrganoBait<\/a>.<\/p>\n

\u201cOur team was focused on a mission to help conserve a vital link in the food chain while also providing numerous advantages and benefits to the crustacean fishing industries,\u201d says Lee Robertson, a research scientist at Kepley BioSystems.<\/p>\n

Early on, Sea Grant saw the value in this new bait technology and supported initial research and field-testing. Based on our preliminary work, we earned additional funding, which led to Phase I and Phase II National Science Foundation Small Business Innovation Research grants, known best as SBIR.<\/p>\n

The goal is to avert the capture of 40 percent of the global forage fish catch by providing a convenient, affordable bait alternative. Indeed, forage fish are an important source of nutrients in our oceans and for many products, including Omega-3 fish oil supplements, pet foods, and agriculture and aquaculture feedstocks.<\/p>\n

OrganoBait is made up of the same naturally occurring molecules found in forage fish that make them so attractive as crab bait. We\u2019re in the final stages of product development and are seeking partners and funding to scale up and commercialize OrganoBait later this year.<\/p>\n

##<\/p>\n","protected":false},"excerpt":{"rendered":"

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